Aneurysms

Patient-specific devices for endovascular treatment of intracranial aneurysms

Medical Need |

Intracranial aneurysms are treated in order to prevent their (re-)rupture. Today, endovascular treatment is often the preferred therapy approach. While the morphologies of aneurysms and their parent vessels vary greatly (Gawlitza et al., 2019), shapes of stents and intrasaccular devices are rather simple and uniform. Still, many aneurysms can only be treated by using devices not according to their actual indications (Gawlitza et al., 2018 & 2016). Additive manufacturing offers the possibility to produce patient-specific devices directly, thus making a high degree of individualization and optimal treatment possible.

Project team members |

Clinician |

TU Dresden, Faculty of Medicine
University Hospital Dresden, Department of Neuroradiology

Project team members |

High-tech |

Fraunhofer Institute for Machine Tools and Forming Technology IWU
Department Medical Engineering

Fraunhofer Institute for Machine Tools and Forming Technology IWU
Department Additive Technologies

Abstract |

Intracranial aneurysms are frequently treated endovascularly using coils, stents and intrasaccular devices. However, aneurysms and their parent vessel are highly variable structures and although a broad armamentarium exists, many of these aneurysms can only be treated by using devices not according to their indications. While patient-specific manufacturing of vascular prostheses in the treatment of aortic aneurysms has been intensively investigated, an attempt in this direction has never been made in endovascular intracranial aneurysm treatment.

In the present project we explore possible applications of patient-specific devices made of superelastic nickel-titanium alloy. We aim to define aneurysm classes in which such personalized therapy approaches may be beneficial. A holistic digital process chain leads to a patient-specific device design, which will then be fabricated by a novel production method in this field called additive manufacturing (also known as 3D-Printing) utilizing laser beam melting (PBF-LB/M). The prototype is tested on an individualized, additively manufactured aneurysm model. Furthermore, the establishment of an animal aneurysm model is envisaged.

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